In some conditions such as prolonged immobility, clots may form within blood vessels. Clot formation in deep veins is called deep vein thrombosis. These clots block the flow of blood in the particular area. They may also dislodge and block blood supply to important organs such as lungs or brain resulting in a stroke or the heart leading to a heart attack. Drugs used to prevent clot formation are called anticoagulants or blood thinners. They should be differentiated from drugs such as aspirin and clopidogrel that prevent the formation of a platelet plug and are referred to as anti-platelet drugs.
Anticoagulants are of two types depending on their route of administration.
► Injectable anticoagulants – These include heparin, low molecular weight heparin, fondaparinux, lepirudin, bivalirudin, argatroban, danaparoid and drotrecogin alfa
► Oral anticoagulant tablets – The main oral anticoagulant tablet used is warfarin. A number of new drugs are undergoing testing before being introduced into the market.
Some anticoagulants are used to prevent clotting of blood when it is collected either for transfusion or blood tests. These include heparin, sodium citrate, sodium oxalate and sodium edetate.
Latest Publications and Research on AnticoagulantsGenotyping of CYP2C9 and VKORC1 in the Arabic Population of Al-Ahsa, Saudi Arabia. - Published by PubMed
Delivery of Optimized Inpatient Anticoagulation Therapy: Consensus Statement from the Anticoagulation Forum (May). - Published by PubMed
Hemorrhage after Transoral Robotic-Assisted Surgery. - Published by PubMed
Management of Hemorrhage Complicated by Novel Oral Anticoagulants in the Emergency Department: Case Report From the Northwestern Emergency Medicine Residency. - Published by PubMed
Low molecular weight heparin in patients undergoing free tissue transfer following head and neck ablative surgery: review of efficacy and associated complications. - Published by PubMed