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Glomerulonephritis Types - Post-infectious Glomerulonephritis
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Glomerulonephritis Types
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Glomerulonephritis Types | |
About Post-Infectious Glomerulonephritis |
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Antibody Mediated
Post-Infectious Glomerulonephritis Infectious agents are the most common inciting antigens associated with immune complex mediated glomerulonephritis. Post-streptococcal glomerulonephritis is the most common form of glomerulonephritis in children and occurs following a skin or pharyngeal infection with Group A beta-hemolytic streptococci. Post-infectious glomerulonephritis has also been associated with other bacterial, viral, parasitic, rickettsial and fungal infections. The precise nature of the antigens involved in the formation of the nephritogenic immune complexes is unknown. Streptococcal antigenic substances have been inconsistently detected in glomeruli and circulating immune complexes have been detected in some patients. Since streptococcal antigens do not always cause disease, other mechanisms may be involved, including alterations in IgG or glomerular components making them immunogenic. Antigens derived from infectious agents may bind to glomerular structures and induce development of in situ immune complexes. Clinical Course Post-streptococcal glomerulonephritis is primarily a disease of children, 6 to 7 years of age. The onset is usually abrupt, with a latent period of 7 to 21 days beteen infection and the development of nephritis. During epidemics, the clinical attack rate is 10-12%, but subclinical disease occurs four times more frequently than overt idsease. Asymptomatic contacts may have hematuria. Antibody Mediated Common initial clinical manifestations of post -streptococcal glomerulonephritis are:
The acute clinical episode of post-streptococcal glomerulonephritis is usually self-limited and complement levels return to normal within 6 weeks. In most patients hematuria disappears by 6 months but proteinuria may persist for two years in a third of patients. Early antimicrobial therapy in affected individuals and family members may prevent the spread of streptococcal infections. Treatment of established infection does not prevent the development of post-streptococcal glomerulonephritis, but may lessen its severity. The prognosis for complete recovery is excellent in children, even in patients with the nephrotic syndrome or crescentic disease at presentation. The prognosis in adults is less favorable, especially when accompanied by initial severe impairment in renal function, persistent proteinuria and the nephrotic syndrome. The development of crescents is more common in adults. |
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Posted by:
breanna
Posted on: 02/04/2010 i was diagnosed with mpgn type 2 at 4 yrs old... it all started with a persistant cold. My mom always thought i was pale but, she had no idea until she found me lethargic on the floor.. my blood pressure was sky high. my urine was black. my 14 yr treatment consisted of aggressive doses of prednisone and blood pressure medication. i also give all the credit in the world to the doctors and staff at the Motts childrens hospital in ann arbor michigan.
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Posted by:
Tamara Harchanko(Guest)
Posted on: 11/13/2008 my stepmom has minimal change disease- she also has rhem.arthritis- last week relapsed into MCD- her ankles are swolen to painful- Is there anybody who knows what foods are for her to eat???? She also suffers from celiac and is under 100 lbs- Please help!!
Posted by:
breanna
Posted on: 07/07/2008 to whom it may concern... I am a 20 year old servivor of MPGN. i was diagnosed at 4 and have now been in remission for 4 years. ive never had a transplant, and although i was very close to it ive never been on dialysis.
Posted by:
no1keene
Posted on: 08/21/2008 Hi bree. Glad to hear you are a survivor of MPGN. I am from ireland and my brothers little girl took this disease 9 weeks ago. She is on dialayis ever day and we are very concerned for her. I would be greatly obliged and grateful to hear the full story of your experiences and any advice you could offer me. Thankyou for you time and take care, colin |
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