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Glomerulonephritis Types - Membranous Glomerulonephritis
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Glomerulonephritis Types
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Glomerulonephritis Types | |
About Membranous Glomerulonephritis |
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Antibody Mediated
Membranous Glomerulonephritis Membranous glomerulonephritis is an antibody mediated disease in which the immune complexes localize to the subepithelial aspect of the capillary loop. That is, between the outer aspect of the basement membrane and the podocyte (epithelial cell) The immune complexes develop in situ or, less likely, by the deposition of circulating immune complexes. The antibody may bind to an intrinsic glomerular antigen or to an exogenous antigen planted on the capillary wall. Approximately 25 to 30% of cases are secondary. Common associations include: 1. Systemic lupus erythematosus and other connective tissue disorders 2. Drugs (gold, penicillamine, non-steroidal anti-inflammatory agents) 3. Hepatitis B, syphilis, quartan malaria, leprosy, schistosomiasis 4. Carcinoma, melanoma, leukemia, non-Hodgkin's lymphomas. Membranous glomerulonephritis is more common in adults and most patients are older than 30 years at diagnosis. Membranous glomerulonephritis accounts for 35-50% of cases of adult nephrotic syndrome. Most patients present with heavy proteinuria, most commonly in the nephrotic range, that is insidious in onset. A few patients have accompanying microscopic hematuria. Antibody Mediated Membranous Glomerulonephritis Membranous glomerulonephritis is more common in adults and most patients are older than 30 years at diagnosis. Membranous glomerulonephritis accounts for 35-50% of cases of adult nephrotic syndrome. Most patients present with heavy proteinuria, most commonly in the nephrotic range, that is insidious in onset. A few patients have accompanying microscopic hematuria. Clinical Course The course of untreated idiopathic membranous glomerulonephritis is variable. Of patients presenting with the nephrotic syndrome and a normal serum creatinine:  30% will have a spontaneous complete remission and a stable GFR for up to 20 years. 25% will have a spontaneous partial remission with a stable GFR (Glomerular Filteration Rate) 20-25% experience persistent nephtrotic syndrome with stable or very slowly progressive loss of GFR. Twenty to 25% of patients progress to end-stage renal failure over a 20 to 30 year follow-up. Patients in whom a causitive agent is identified, usually respond to treatment of the underlying disorder, or withdrawl of the offending agent. |
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Posted by:
breanna
Posted on: 02/04/2010 i was diagnosed with mpgn type 2 at 4 yrs old... it all started with a persistant cold. My mom always thought i was pale but, she had no idea until she found me lethargic on the floor.. my blood pressure was sky high. my urine was black. my 14 yr treatment consisted of aggressive doses of prednisone and blood pressure medication. i also give all the credit in the world to the doctors and staff at the Motts childrens hospital in ann arbor michigan.
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Posted by:
Tamara Harchanko(Guest)
Posted on: 11/13/2008 my stepmom has minimal change disease- she also has rhem.arthritis- last week relapsed into MCD- her ankles are swolen to painful- Is there anybody who knows what foods are for her to eat???? She also suffers from celiac and is under 100 lbs- Please help!!
Posted by:
breanna
Posted on: 07/07/2008 to whom it may concern... I am a 20 year old servivor of MPGN. i was diagnosed at 4 and have now been in remission for 4 years. ive never had a transplant, and although i was very close to it ive never been on dialysis.
Posted by:
no1keene
Posted on: 08/21/2008 Hi bree. Glad to hear you are a survivor of MPGN. I am from ireland and my brothers little girl took this disease 9 weeks ago. She is on dialayis ever day and we are very concerned for her. I would be greatly obliged and grateful to hear the full story of your experiences and any advice you could offer me. Thankyou for you time and take care, colin |
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