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Glomerulonephritis Types - Focal Segmental Glomerulosclerosis
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Glomerulonephritis Types
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Glomerulonephritis Types | |
Cell mediated Injury |
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Focal Segmental Glomerulosclerosis Focal segmental glomerulosclerosis comprises 10% of childhood and 15-20% of cases of adult idiopathic nephrotic syndrome. Patients present with proteinuria and microscopic hematuria. Hypertension is also common. The pathogenesis of the sclerosing lesions and their progressive nature are debated. Humans with idiopathic focal segmental glomerulosclerosis initially have a high glomerular filtration rate and evidence of hyperfiltration, suggesting that hyperfiltration and increased intracapillary glomerular pressure may be mediators of this disease. A similar pattern of segmental sclerosis may be seen in a number of distinct glomerular diseases with different pathogenetic mechanisms and clinical courses (eg. IgA nephropathy). Clinical Course Focal segmental glomerulosclerosis may be primary (idiopathic) or secondary to a number of etiologic agents including:  Unilateral renal agenesis Renal ablation Sickle cell disease Morbid obesity (with or without sleep apnea) Congenital cyanotic heart disease Heroin nephropathy HIV nephropathy Aging kidney Steroid therapy may induce remission in 20-40% of children and fewer adults. Adults progress to renal failure rapidly over 2-3 years (15-20%) or more slowly over 10-12 years. Focal segmental glomerulosclerosis commonly recurs following transplantation (50-80%). |
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Posted by:
breanna
Posted on: 02/04/2010 i was diagnosed with mpgn type 2 at 4 yrs old... it all started with a persistant cold. My mom always thought i was pale but, she had no idea until she found me lethargic on the floor.. my blood pressure was sky high. my urine was black. my 14 yr treatment consisted of aggressive doses of prednisone and blood pressure medication. i also give all the credit in the world to the doctors and staff at the Motts childrens hospital in ann arbor michigan.
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Posted by:
Tamara Harchanko(Guest)
Posted on: 11/13/2008 my stepmom has minimal change disease- she also has rhem.arthritis- last week relapsed into MCD- her ankles are swolen to painful- Is there anybody who knows what foods are for her to eat???? She also suffers from celiac and is under 100 lbs- Please help!!
Posted by:
breanna
Posted on: 07/07/2008 to whom it may concern... I am a 20 year old servivor of MPGN. i was diagnosed at 4 and have now been in remission for 4 years. ive never had a transplant, and although i was very close to it ive never been on dialysis.
Posted by:
no1keene
Posted on: 08/21/2008 Hi bree. Glad to hear you are a survivor of MPGN. I am from ireland and my brothers little girl took this disease 9 weeks ago. She is on dialayis ever day and we are very concerned for her. I would be greatly obliged and grateful to hear the full story of your experiences and any advice you could offer me. Thankyou for you time and take care, colin |
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