More Information on Glomerulonephritis
Cell mediated Injury
Injury to glomeruli results in a variety of signs and symptoms of disease including:
altered permeability of capillary walls.
loss of capillary wall integrity.
impaired filtration of nitrogenous wastes.
reduced or absent urine production.
loss of intravascular oncotic pressure.
fluid retentionand altered renal regulation of blood pressure.
Several syndromes related to glomerulonephritis have been described.
Nephrotic syndrome: Proteinuria in excess of 3.5 grams in 24 hours, accompanied by edema, hypoalbuminemia, hyperlipidemia and lipiduria.
Acute nephritis or the Nephritic syndrome: Hematuria, variable proteinuria, azotemia, and hypertension.
Rapidly progressive glomerulonephritis: Hematuria, oliguria and acute renal failure.
Although much overlap exists, glomerular diseases may be classified by their predominant clinical manifestations.
|Nephroti Syndrome||Nephritic Syndrome|
|Minimal change disease||+++++||-|
|Focal segmental glomerulosclerosis||++++||+|
|Acute post-infectious GN||+||++++|