Gender - Men are affected more than women

Age - Individuals between 15-40 years of age are most commonly affected .

Hereditary - Heredity plays a major role in predisposing the disease. Ankylosing spondylitis is present in persons whose relatives are already affected by it.

Tissue type - Ankylosing spondylitis is related to certain tissue types. Majority of persons affected with Ankylosing spondylitis are found to belong to HLA-B-27 type of tissue.

Colon Ulcers - Patients with bowel ulcers are under risk of developing Ankylosing Spondylitis.

Reiter's disease - Reiter's disease is a joint disease, where all the joints of the body are affected. Patients affected by Reiter's disease are more susceptible to Ankylosing Spondylitis.