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Medindia » Consumer Health » Health Information » Acute Lymphoblastic Leukemia - Prognosis

Acute Lymphoblastic Leukemia

Prognosis
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Prognosis of the ALL patient depends on several parameters. Younger patients have better chances of survival compared to older ones.
Patients with ALL are divided into 3 prognostic groups-

Favorable prognosis group includes:

     - No adverse cytogenetic abnormalities
     - Age younger than 30 years
     - WBC count of less than 30,000/µL
     - Complete remission within 4 weeks.

Intermediate risk group does not meet the criteria for either good risk or poor risk.

Poor risk group includes:

    - Adverse cytogenetics [(t9; 22), (4; 11) genetic translocations]
    - Age older than 60 years
    - Precursor B-cell WBCs with WBC count greater than 100,000/µL
    - Failure to achieve complete remission within 4 weeks

Table 1-Correlation between cytogenetic abnormalities and prognosis
Cytogenetic Abnormality Genes Involved Event-Free Survival (3 yrs)
 t(10;14)(q24;q11)  HOX11/TCRA  75%
 6q  Not Known  47%
 14q11  TCRA/TCRD  42%
 11q23  MLL  18-26%
 9p  Not Known  22%
 12  TEL  20%
 t(1;19)(q23;p13)  PBX1/E2A  20%
 t(8;14)(q24;q23)  t(2;8)(p12;q24)  t(8;22)(q24;q11)  c-myc/IGH  IGK/c-myc  c-myc/IGL  17%
 t(9;22)(q34;q11)
 Philadelphia chromosome 		 bcr-abl  5-10%
 t(4;11)(q21;q23)  AF4-MLL  0-10%
Table 2. Correlation between Ploidy (Chromosome Number) and Prognosis
Ploidy Event-Free Survival(3 yrs)
 Near tetraploidy  46-56%
 Diploidy(Normal karyotype)  34-44%
 Hyperdiploidy >50  32-59%
 Hyperdiploidy 47-50  21-53%
 Pseudodiploidy  12-25%
 Hypodiploidy  11%

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If you have a question about health related issues, you can now post it in our Ask An Expert section on our community website Medwonders.com and get answers from our panel of experts.
Posted by:  satzjeez  Posted on: 04/28/2012
DO A HEART PATIENT GET CLL OR ALL OR AML OR CML

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Posted by:  Toni95(Guest)  Posted on: 08/22/2011
Non of this has helped me with my research :/ my sister has leukemia and none of the stuff above is even close!!

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Posted by:  jasperkumar(Guest)  Posted on: 07/17/2010
i had ALL WEN I WAS 10. I was treated for a year and i was good for 10 years but i was diagnosed for ALL wen I WAS 20 . I was treated and i am okay now. is this possible?

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Posted by:  ParisDaniels  Posted on: 04/19/2010
I think the best way to combat is to educate yourself about it. This will help you recognize the symptoms and therefore prevent the spread of cancer cells. I appreciate you sharing this to us.

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Posted by:  winnie34  Posted on: 10/07/2009
my friend is experiencing a multlitude of incredibly itchy skin swellings, bumps, some of which have turned into warts as they heal. doctors have been unable to either diagnose or find a remedy. any news?

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