This plan was introduced keeping in mind the biochemical aspect, which deals with hormones in this case. Insulin, the hormone secreted by pancreas in our body works on the blood sugar and keeps it under control. Complication in this
regard is the main cause of diabetes.
Excess of insulin can increase fat storage and inflammation in the body. According to Sears by using the Zone Diet one actually optimises the body's metabolic function. Through the regulation of blood sugar the body burns excess body fat. In Zone Diet the insulin and eicosanoids hormones are kept in a Zone by the food eaten and results in burning of fat.