X-Ray to Study the Atomic Composition of Micronutrients in Human Minibrains

It is very clear that mothers' diet during pregnancy has long-term effects on fetal development. Micronutrients and minerals play a key role during human fetal development. Until today, the study of nutrients in brains was restricted to postmortem or non-human tissue.

A study published in PeerJ this week describes the composition and distribution of some elements in human minibrains created in the lab. Human brain organoids - tiny tridimensional structures created from human stem cells in vitro - helped to understand the dynamics of nutrients during neurodevelopment.

Maternal Multiple Micronutrients Supplementation Leads to Reductions in Preterm Births and Low Birth Weight
Daily maternal supplementation with multiple micronutrients was compared to iron-folic acid supplementation before and after childbirth.

‘Using synchrotron radiation, a sort of X-ray, researchers studied the composition and distribution of some elements in human minibrains. It has helped to understand the dynamics of nutrients during neurodevelopment.’

Tweet it Now

Researchers analyzed human brain organoids, also known as minibrains, by synchrotron radiation, a sort of X-ray that allows the identification of the atomic composition of micronutrients. This technique consists of exciting tissue samples in order to quantify the unique photon signature of each atom. In doing so, they described how phosphorus, sulfur, potassium, calcium, iron and zinc are distributed during brain formation.

Simone Cardoso, Associate Professor at the Institute of Physics at Federal University of Rio de Janeiro, highlights the interdisciplinary nature of the study, which involved biologists and physicists. "This allows us to gather a wide range of scientific expertise to plan and perform the experiments".

The minibrains were up to 45-days old. The authors described the distribution of nutrients in two different stages of development: an initial one, of intense cellular proliferation (day 30); and at a second time point, when cells start to become neurons and organize themselves into layers (day 45).

Mineral Deficiency - What Should You Know?
Mineral deficiency is a condition in which the concentration of an essential mineral element in the body becomes very low and leads to impairment of function.

The results show that the concentration and distribution of micronutrients are related to the stage of development and similar to previous data obtained from postmortem brain samples.

The observed nutrients are essential for the appropriate formation of the brain. The lack of some of them during prenatal development is also related to memory deficits and psychiatric disorders, such as schizophrenia.

Study Says Exposure to Micronutrients Pre-pregnancy Associated With Gene Modifications in Offspring
Babies of women who were given micronutrient supplements before they become pregnant had gene modifications at birth, reveals study.

"This study reinforces how important minibrains can be as a model to investigate several aspects of brain development", says Stevens Rehen, the principal investigator of the study and a researcher working at the D' Or Institute for Research and Education (IDOR) and at the Institute of Biomedical Sciences at Federal University of Rio de Janeiro in Brazil.

Source-Eurekalert

Micronutrients Influence Prostate Cancer Risk
Vitamin intake may influence prostate cancer risk beneficially or adversely, depending on the type and dose of the vitamin.