Women Fare Better Than Men One Year After Heart Valve Replacement

by Bidita Debnath on  December 20, 2016 at 11:42 PM Heart Disease News
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Women with significant aortic valve disease who undergo transcatheter aortic valve replacement (TAVR) are considered at higher risk than men in some respects.
 Women Fare Better Than Men One Year After Heart Valve Replacement
Women Fare Better Than Men One Year After Heart Valve Replacement

However, their survival rate one year after having had the procedure is higher than men, according to a study published in the Journal of the American College of Cardiology.

Even though women have more complications as a result of the TAVR procedure--especially bleeding and vascular issues--they still fared better than men one year after the procedure. The reasons for this are not yet completely understood.

Previous studies have looked at the early outcomes after TAVR in men and women, and shown that the survival rate was the same for both sexes. However, this is the largest study to take an in-depth look at the longer-term outcomes and survival rates after TAVR in women and men.

TAVR is a minimally invasive treatment method used for people with severe symptomatic aortic valve disease who are at high risk, and about half of patients who undergo this procedure are women. To decide who should have TAVR versus another type of procedure, such as surgical aortic valve replacement (SAVR) or medical therapy, surgeons and heart teams calculate a person's risk by using scoring methods that determine their 30-day mortality and morbidity risks. However, these scoring methods were generally designed to predict risk as it relates to SAVR, not TAVR.

"These findings are significant because it may mean heart teams are overestimating the risks of TAVR in some women and that also may mean that valve replacement is underutilized," said Roxana Mehran, M.D., professor of medicine in cardiology at The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai and the study's senior researcher. "In other words, some women who could benefit from TAVR may not be getting it."

Using data from the STS/ACC TVT Registry, the study looked at more than 23,000 patients receiving TAVR with older generation devices between 2011 and 2014 with an almost equal proportion of women (49.9 percent) and men (51.1 percent).

In general, the women were older and had higher predicted 30-day risk scores. However, they were more likely to have other health issues at baseline, such as worsened kidney function, significant problems related to a leaking mitral heart valve and "porcelain aorta" which is when the aorta--the main artery of the body--becomes heavily calcified.

Men were more likely to be treated with percutaneous TAVR which is when a tube is inserted through the skin into the artery in the groin. Women were more likely to have a surgical incision for TAVR. Additionally, although very rare, there was a greater chance that the operating cardiologist or surgeon would need to abort TAVR and switch over to open surgery--due to complications--in women.

Overall, despite the fact that women had more procedural problems, they had better survival at one year. In addition, with smaller and improved TAVR devices, women can increasingly undergo procedures percutaneously via the smaller artery in the groin, which would be expected to reduce the risk of procedural complications as well.

"These study results also highlight that we need a robust scoring assessment that is specific to TAVR and catered to women so we can make the best decisions," Mehran said. "Additionally, further study is needed on the medium- to long-term causes of death in men and women who have had TAVR, particularly studies that are focused on learning more about vascular biology and why the aorta becomes more calcified in women."

Mehran also said that there are promising advances being made in 3D printing technology that will improve devices used in TAVR. As a result of improved technology, outcomes will likely further improve in both men and women.

In an accompanying editorial, Molly Szerlip, M.D., a cardiologist at The Heart Hospital Baylor Plano in Plano, Texas, said, "One should, however, interpret the results of this study with caution. The findings of this study are only applicable to the population that was studied and should not necessarily be extrapolated to lower risk populations or to patients who receive newer generation valves."

Source: Eurekalert

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