White Matter Hyperintensities Second Necessary Factor for Development of Alzheimer's Disease

by Bidita Debnath on  February 21, 2013 at 11:12 PM Research News
RSS Email Print This Page Comment
New findings by Columbia researchers suggest that for the development of Alzheimer's disease, along with amyloid deposits, white matter hyperintensities (WMHs) may be a second necessary factor.
 White Matter Hyperintensities Second Necessary Factor for Development of Alzheimer's Disease
White Matter Hyperintensities Second Necessary Factor for Development of Alzheimer's Disease
Advertisement

Most current approaches to Alzheimer's disease focus on the accumulation of amyloid plaque in the brain. The researchers at the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, led by Adam M. Brickman, PhD, assistant professor of neuropsychology, examined the additional contribution of small-vessel cerebrovascular disease, which they visualized as white matter hyperintensities (WMHs).

Advertisement
The study included 20 subjects with clinically defined Alzheimer's disease, 59 subjects with mild cognitive impairment, and 21 normal control subjects. Using data from the Alzheimer's Disease Neuroimaging Initiative public database, the researchers found that amyloid and WHMs were equally associated with an Alzheimer's diagnosis. Amyloid and WMHs were also equally predictive of which subjects with mildcognitive impairment would go on to develop Alzheimer's. Among those with significant amyloid, WMHs were more prevalent in those with Alzheimer's than in normal control subjects.

Because the risk factors for WMHs—which are mainly vascular—can be controlled, the findings suggest potential ways to prevent the development of Alzheimer's in those with amyloid deposits.

"White Matter Hyperintensities and Cerebral Amyloidosis" was published online today in JAMA Neurology.

Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Diet and Alzheimer´s Disease Genetics of Alzheimer´s disease 
Advertisement

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive