What Makes Smoking So Terribly Addictive

by Bidita Debnath on  December 31, 2013 at 9:43 PM Research News
RSS Email Print This Page Comment
Font : A-A+

Researchers have explained how nicotine exploits the body's cellular machinery and promotes addiction.
 What Makes Smoking So Terribly Addictive
What Makes Smoking So Terribly Addictive

According to the Center for Disease Control and Prevention, nicotine activates receptors known as nAChRs and, remarkably, unlike most other drugs of abuse, it acts as a "pharmacological chaperone" to stabilize assembly of its receptors within the Endoplasmic Reticulum (ER) and increase their abundance at the cell surface (up-regulation).

Up-regulation of nAChRs plays a major role in nicotine addiction and, possibly, in the decreased susceptibility of smokers to Parkinson's disease.

Receptors containing an alpha6 subunit (alpha6* nAChRs) are abundant in several specific brain regions.

Researchers from the California Institute of Technology in Pasadena used mice expressing alpha6 labeled with a fluorescent protein to show that exposure to nicotine-at a level comparable to that in human smokers-up-regulated alpha6* nAChRs in these areas of the brain.

The study has been published in The Journal of General Physiology.

Source: ANI

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Health Hazards of Smoking Smoking And Cancer Smoking And Tobacco Diet Lifestyle and Heart Disease Bubbles and Brews - Alcohol Facts Smoking Cigarette Smoking - A Silent Killer Chronic Obstructive Pulmonary Disease Leriche Syndrome Antioxidants to Help You When You Quit Smoking 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive