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Patients with HIV-1 can predict plasma lipids level based on race

by Medindia Content Team on  January 25, 2006 at 7:24 PM Research News   - G J E 4
Patients with HIV-1 can predict plasma lipids level based on race
It is a known fact that your race has a profound effect on your health status. Confirming that study is a research held at University of Massachusetts and Pennsylvania which shows that race/ethnicity is a predictor of plasma lipids in patients with HIV-1 on HAART (highly active antiretroviral therapy).
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The study was conducted on 626 patients participating in several ongoing AIDS Clinical Trial Group studies. The main thrust was to look at the way that race/ethnicity, genetic variants of lipoproteins apoC-III/apoA-I, and protease inhibitors (a class of drugs used against HIV) affected plasma lipids.

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Overall, Black patients on HAART had a lipid profile more likely to be less prone to atheroma than White and Hispanic patients.

HIV-1 infection has become a chronic, manageable condition for patients who have long-term access to highly active antiretroviral therapy. Some protease inhibitors have been associated with elevated levels of cholesterol, triglyceride, and low high-density lipoprotein cholesterol. These findings are believed to be the first evidence for race/ethnicity-specific differences in both the occurrence of dyslipidemia on antiretroviral therapy (ART) and the influence of genetic factors on the occurrence of protease inhibitor-related lipid abnormalities.
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