Gene Therapy To Cure Parkinson's Disease

by Medindia Content Team on  January 22, 2006 at 5:21 PM Mental Health News
RSS Email Print This Page Comment
Gene Therapy To Cure Parkinson's Disease
A novel gene therapy is being developed by scientists belonging to the Northwestern University targeted at turning off some genes which contribute towards Parkinson's disease. The gene therapy, described in the January online issue of the journal Experimental Neurology, was designed by Martha Bohn and her laboratory group at Northwestern University Feinberg School of Medicine.
Advertisement

Bohn is a Medical Research Council Professor and director of the neurobiology program at Children's Memorial Research Center and professor of pediatrics and of molecular pharmacology and biological chemistry at the Feinberg School.

Advertisement
The gene technique the Bohn lab developed removes a protein known as alpha-synuclein from the diseased dopamine-producing neurons that die in Parkinson's disease. Alpha-synuclein is abundant in structures known as Lewy bodies, a diagnostic hallmark of Parkinson's disease. Research has shown that mutant forms of the alpha-synuclein gene, as well as too much alpha- synuclein protein, are involved in the development Parkinson's disease in some families.

For this research, the Bohn lab combined a recently developed technology called 'RNA interference' with gene therapy to turn off alpha-synuclein in dopamine neurons. RNA interference is a sophisticated method to selectively turn off one gene in a cell, leaving others unaffected.

'This is the first step in developing a new therapy for Parkinson's disease based on molecular knowledge of the disease,' said Mohan K. Sapru, research assistant professor of pediatrics, who is first author on the study and co-inventor of the gene therapy technology.

'It may also be useful for other diseases of the brain, such as dementia with Lewy bodies, a disease also characterized by Lewy bodies in the brain, Sapru added.

Edited (ANI)
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

DNA Finger Printing Reiki and Pranic Healing Genetic Testing of Diseases Pancreas Niemann-Pick Disease Nutritional Management of Parkinsons disease 
Advertisement

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive