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Leptin and inflammatory cytokines in women with pre-eclampsia

by Medindia Content Team on  November 7, 2005 at 12:41 PM Research News   - G J E 4
Leptin and inflammatory cytokines in women with pre-eclampsia
Recent research shows that in women with pre-eclampsia, the level of maternal serum leptin is increased and correlates positively with the level of inflammatory cytokines, TNF-.
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The research was conducted at University Hospital of Puerto Real, Cadiz, Spain to compare maternal serum leptin concentration in women with pre-eclampsia and women with normal pregnancy, and to evaluate the relationships between leptin and several inflammatory cytokines.

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The study appears in the December issue of British Journal of Obstetrics and Gynaecology.

Leptin is a hormone that regulates metabolic efficiency, energy expenditure, and food intake. It is mainly produced in adipose cells, but in humans, m-RNA encoding leptin is also present in the placenta.

Pre-eclampsia is associated with an increase in maternal plasma leptin concentration, and it has been demonstrated that placental production of leptin is augmented in women with severe pre-eclampsia

Twenty-seven women with pre-eclampsia and 25 normotensive pregnant women were enrolled for the study. Maternal serum levels of TNF-, TGF-1, interleukin 6, and leptin were measured using a commercially available immunoassay.

The authors conclude that the level of maternal serum leptin is increased and correlates positively with the level of TNF- in women with pre-eclampsia. In women with a normal pregnancy leptin levels not only correlate with TNF-, but also with IL-6 and body mass index.
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