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Sequencing of the Plague

by Medindia Content Team on  October 9, 2001 at 6:18 PM Research News   - G J E 4
Sequencing of the Plague
Bubonic plague, the bacterium blamed for the Black Death during middle ages in Europe and now a potential biological weapon, has had its entire genome sequenced. The genes seem to be "unusually fluid", readily re-arranging themselves and picking up new genes from other microbes. That could mean that more virulent strains of plague might emerge. More ominously, it suggests that enhanced strains might be relatively easy to develop as weapons.
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The bacillus that causes bubonic plague, Yersinia pestis, commonly infects rodents in Asia, Africa and the Americas. But it occasionally spreads to humans, with fatal effect.It does so by infecting both insects and mammals. Fleas that feed on infected rodents swallow the bacteria, which infect and block their midguts. The starving fleas feed ravenously, but only regurgitate the blood they try to swallow - along with the bacteria. So plague spreads among rodents, often causing only mild disease.

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If the infected flea bites a human, however, up to half the victims die, unless treated with antibiotics. If the bacteria invade the lungs of such patients, and they cough them out, nearby people may catch "pneumonic" plague. This is always fatal without treatment.

Pneumonic plague is the form feared as a latent biological weapon, as it can be released as an aerosol and can spread directly among humans, without the interposition of fleas.Russia developed such a plague weapon.

It picked up genes directly from baculoviruses that infect insects, including one for a toxin that damages the midgut. It also acquired "pathogenicity islands", by assembling of genes from other bacteria that help cause human disease.

The sequence also reveals new surface molecules, which might provide new ways to attack plague. But "this genome displays unusual fluidity," comment Stewart Cole and Carmen Buchreiser in the magazine Nature, where the genome is published. Numerous Yersinia genes have been copied backwards and have exchanged positions within the genome, sometimes creating different variants in the same population.

These recombinations could mean differences in virulence in a single batch of plague, they note. That could also mean that the bacteria - or bioweapons developers - have the genes at their disposal for new and potentially vexatious strains of disease.

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