New Technique To Test Stem Cells That Heal The Heart

by Medindia Content Team on  September 6, 2005 at 5:39 PM General Health News
RSS Email Print This Page Comment
<b>New Technique To Test Stem Cells That Heal The Heart</b>
Researchers from the Johns Hopkins Department of had discovered a new way to test the stem cells journey in the heart after a heart attack.
Advertisement

The researchers had used a non-invasive imaging technique, called SPECT/CT, to successfully trace stem cells' destinations after being injected into the body to treat animal hearts damaged by myocardial infarction, or heart attack.

Advertisement
In the study, researchers surgically induced acute myocardial infarctions in seven dogs, six of which later received canine mesenchymal stem cells (MSCs) labeled with a radioactive tracer and magnetic resonance imaging (MRI) contrast agent to enhance image quality. Both the tracer and contrast agent are widely used in research and routine clinical practice.

The internal distribution of the injected stem cells was tracked with SPECT/CT and MRI scanners immediately after injection as well as at multiple time points over seven days to assess whether the MSCs preferentially migrated or "homed" in on damaged cardiac tissue. Previous studies in animals were only able to demonstrate homing by examining the tissue microscopically after death.

The team's results, reported in the latest issue of Circulation, revealed redistribution of the radio-labeled MSCs from the initial localization in the lungs to the target organ, the heart, at 24 hours post-injection. Moreover, the cells remained visible in SPECT/CT images until seven days after the injection.

SPECT/CT also found redistribution of the MSCs to non-target organs, such as the liver, kidney and spleen. Measuring the radiation levels in tissues obtained from the animals after their death validated these findings.

MRI, because of its lower sensitivity, was unable to demonstrate targeted cardiac localization of MSCs.
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Bone Marrow Transplantation Tissue Engineering and Regenerative Medicine Stem Cells 
Advertisement

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive