Surgeons, in a study published in The Lancet, have proposed treating burst aneurysms with platinum coils instead of brain surgery.
In 2002 the International Subarachnoid Aneurysm Trial (ISAT) was stopped early because it showed that the minimally invasive technique, coiling, was more likely to result in survival without disability at one year when compared to neurosurgical clipping. The traditional neurosurgical treatment involves a craniotomy and clipping of the aneurysm to stop further bleeding. The coiling treatment is performed by way of a tiny puncture wound in the groin and through the blood vessels.
AdvertisementAt the time of the first report the 1-year follow-up data was available for only 1594 of the 2143 patients enrolled and long-term follow up was not available. Now the researchers report the complete 1-year data and results of long-term follow-up.
Researchers from University of Oxford had recruited 2143 patients from 42 neuro-surgical centers in Europe, North America, and Australia. The investigators found that 250 of 1063 (23·5%) patients allocated to endovascular coiling treatment were dead or dependent at one year compared with 326 of 1055 (30·9%) patients allocated to neuro-surgery and clipping. The researchers found that the early survival advantage was maintained up to 7 years. They also found that the risk of late rebleeding was low but more common after endovascular coiling than after neurosurgical clipping. Patients assigned coiling also had a substantially lower risk of seizures than patients allocated to clipping.
According to the researchers, the complete 1-year data from ISAT confirm and reinforce our preliminary findings. Minimally invasive endovascular coil treatment of ruptured brain aneurysms, when a patient is in good clinical condition and the aneurysm is suitable for coiling, is more likely to lead to independent survival at 1 year than neurosurgical clipping.
Source: Newswise, The Lancet