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A Protein That Increases Risk Of Tumours

by Medindia Content Team on  August 12, 2005 at 5:57 PM General Health News   - G J E 4
A Protein That Increases Risk Of Tumours
A protein that protects the body from tissue damage also increases the risk of tumours, says a study.

Researchers at Washington University School of Medicine in St. Louis tested the protein Bcl-xL that helps the body's healthy cells survive the effects of toxic chemotherapeutic agents.
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They also found that the protein encourages the growth of tumours in mice exposed to a carcinogen, reports the science portal eurekAlert.

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The study compared the effect of urethane, a lung-specific carcinogen, on two sets of mice -- wild-type mice, which have two functional genes that express Bcl-xL, and transgenic mice that have only one functional gene expressing the protein.

Because they have only one of the genes, transgenic mice produce less Bcl-xL. After exposure to urethane, 40 percent of wild-type mice developed seven or more lung tumours, while no transgenic mice developed more than seven tumours. Furthermore, wild-type mice on average had larger tumours than transgenic mice.

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