Low immunity in people with multiple sclerosis may be genetical

by Medindia Content Team on  June 26, 2005 at 10:33 AM General Health News
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Low immunity in people with multiple sclerosis may be genetical
People who have low immunity that had lead to inability to curbing of inflammatory cells and cause multiple sclerosis may have genes that act likewise. Researchers from Oregon Health & Science University have reported that the FOXP3 gene may be responsible for the low immune problem that leads to progress of multiple sclerosis.

Multiple sclerosis is a chronic neurological disease of the central nervous system. There is no cure for this disease but modern day treatment may slow the course of development or give relief from some of the symptoms of this disease.

Researchers are of opinion that FOXP3 gene, found in the subset of T-cells, regulates the immunity of the body against multiple sclerosis and other autoimmune diseases like diabetes and arthritis. This is the first study that establishes an association between multiple sclerosis and the FOXP3 gene. The research suggests that lower expression of the FOXP3 gene suppresses the functions of the regulatory T cells. This leads to the body's inability to control the inflammatory cells that in turn attack the nerve fibers. This leads to the increased incidence of multiple sclerosis disease on people.

Reference: Journal of Neuroscience Research, July 2005

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