Medindia

X

New gene therapy for Alzheimer’s

by Medindia Content Team on  May 6, 2005 at 3:52 PM General Health News   - G J E 4
New gene therapy for Alzheimer’s
Scientists had been able to treat Alzheimer's disease with gene therapy

Alzheimer's disease affects the brain cells and slowly destroys them. The main symptoms of the disease are decreasing memory, ability to reason, creative abilities and learning powers.
Advertisement

One of the main features of this disease is the destruction of cholinergic neurons. The new trials target a genetic change in the nerve growth factor. Nerve growth factor (NGF) stimulates cholinergic function, improves memory and prevents cholinergic degeneration in animal models of injury, amyloid over _expression and ageing. The scientists have delivered NGF gene in eight individuals with mild Alzheimer's disease. They had followed up the patients for 22 months and found no side effects or adverse reactions in them.

Advertisement
Scientists had used Mini-Mental Status Examination and Alzheimer Disease Assessment Scale-Cognitive subcomponent on the patients to follow the course of the disease. Resultant examination showed improvement in the rate of cognitive decline. Also serial pet scans had showed significant increases in cortical 18-fluorodeoxyglucose after treatment. Brain autopsy from one patient showed good improvement in cells in response to nerve growth factor.

The research was featured in the journal The Lancet.
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All