A reduction in inflammation can be achieved by a diet high in oily fish in combination with low doses of aspirin, such as salmon or mackerel. This is supported by the identification of an anti - inflammatory lipid in humans derived from an essential fatty acid in fish oil.
Fatty fish is known to contain large amounts of omega-3 fatty acids. Eating fatty fish is beneficial to patients with cardiovascular disease, arthritis, Alzheimer's disease, and asthma by reducing disease and inflammation.
A new class of aspirin-triggered bioactive lipids called resolvins was identified, which may in part explain why omega-3 fatty acids have beneficial effects. Resolvins are made from the omega-3 fatty acids by cellular enzymes and can reduce inflammation in mice.
Resolvins were also identified in humans. Volunteers given omega-3 fatty acids and aspirin were found to have resolvins in their plasma. Human resolvins were shown to inhibit the movement of inflammatory cells.