Enhancing Survival Rate Of Lung Cancer Patients

by Medindia Content Team on  November 8, 2004 at 5:05 PM General Health News
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Enhancing Survival Rate Of Lung Cancer Patients
Investigators in an international study found the survival rate of non-small-cell lung cancer patients after its removal improved with cisplatin-based adjuvant chemotherapy. Cisplatin is an anti-neoplastic medication that interferes with the growth of cancer cells and slows their growth and spread in the body.
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Researchers randomly assigned 1,867 patients to receive either three or four cycles of cisplatin-based chemotherapy or observation. In addition to cisplatin, the drug etoposide was given to about 56 percent of patients; the drug vinorelbine was given to about 26 percent of patients; vinblastine was given to 11 percent of patients, and vindesine was given to nearly 6 percent of patients. Of the 932 patients assigned to chemotherapy, nearly 73 percent received at least 240 milligrams of cisplatin per square meter of body-surface area.

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Results of the study showed that after five years, patients assigned to chemotherapy had a significantly higher survival rate at 44.5 percent than those assigned to observation who had a 40.4 survival rate at five years. Patients assigned to chemotherapy also had a significantly higher disease-free survival rate at 39.4 percent than those assigned to observation with 34.3 percent.

Thus researchers say their results indicate that roughly 7,000 deaths from non-small-cell carcinoma would be averted annually with the use of adjuvant cisplatin-based chemotherapy.
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