SARS vaccine shows promise in Animal Testing

by Medindia Content Team on  April 3, 2004 at 10:03 AM Drug News   - G J E 4
SARS vaccine shows promise in Animal Testing
SARS, or severe acute respiratory syndrome, is a coronavirus. Similar viruses infect the pigs and other animals. It emerged in southern China in late 2002 and spread to more than two dozen countries on four continents before it was contained last summer. More than 8,000 people worldwide were sickened, and at least 774 died.Civet cats and other mongoose-like animals that are sold in live food markets in southern China are suspected of spreading SARS to humans although the original source of the virus has not been determined.

Researchers say mice immunized with an experimental SARS vaccine were protected against the deadly respiratory disease Results from an accelerated federal research program show the vaccine prompted an immune response in the mice and dramatically reduced the level of the virus in the lungs of some mice.

However the results lead to mixed opinions , some researchers say more experiments are needed to determine if it will work in humans. Some scientists not connected with the study said the results were encouraging, but should not be overstated. No DNA vaccine has yet been shown to effectively treat any viral disease and the approach is still unproven compared to conventional vaccines.

Vaccines are normally made from dead or weakened viruses and work by mobilizing the body's immune system to build defenses by showing it what the targeted virus looks like. That approach is used every year, for example, to develop flu shots to combat emerging strains of influenza.

But the SARS vaccine was made from a small piece of genetic material from the virus called a plasmid. It biochemically locks onto a specific protein on the outer surface of the virus. This alerts the body's immune system to launch a counterattack against the invading virus.

Scientists tested two versions of the DNA vaccine in 15 mice over a six-week period. The vaccines differed in how much genetic material scientists removed from the original piece of DNA. Both worked, although one appeared to be more effective than the other.

Earlier this year, China announced plans to test on humans an experimental SARS vaccine that uses a killed virus. The vaccine had been shown to be effective in animal testing.

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