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Missing Protein In Cancer Development

by Medindia Content Team on  May 3, 2003 at 7:42 PM General Health News   - G J E 4
Missing Protein In Cancer Development
A research indicates lack of protein to development of cancer. Cells without this protein are usually rendered genetically unstable. Such instability would either kill a cell or keep it from growing. However sometimes mutations alter cells in such a way that they are able to multiply creating tumors. Researchers indicated that loss of E2F3 itself doesn't cause cancer but its absence gives a normal cell the chance to change into a cancer cell. E2F3 is part of a family of proteins called transcription factors. They are critical for controlling the entire cell cycle. The protein is responsible for transmission of genetic material from a parent cell to each of its daughter cells produced during cell division. If that transmission somehow gets disrupted, the resulting cells become mutant versions of the original cell. The researchers studied mouse cells that lacked E2F3 as well as cells that contained the protein. The cells were grown in culture dishes in a laboratory. The researchers were particularly interested in the behavior of centrosomes structures inside a cell. After studying mouse cells, the researchers determined that E2F3 keeps the number of centrosomes under control, and that extra centrosomes result when this transcription factor is missing. The consequences are severe for a cell whose centrosome duplication is disrupted. The cells in many human tumors have too many centrosomes. This proliferation of centrosomes may be key in the progression of breast, prostate and colon tumors. However there are other factors involved in this process. What is identified an just an regulator.

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