Stem Cells to Treat Liver Cancer

by Medindia Content Team on  March 27, 2007 at 7:59 PM Genetics & Stem Cells News
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Stem Cells to Treat Liver Cancer
When large, fast-growing cancers invade the liver, some patients are unable to undergo surgery, because removing the cancerous tissue would leave too little liver to support the body.

A new research has thrown light on a possible therapy for such patients. Researchers at Heinrich-Heine-University in Düsseldorf, Germany, used adult bone marrow stem cells to help quickly regenerate healthy liver tissue, enabling patients to eventually undergo a surgical resection.

'Our study suggests that liver stem cells harvested from the patient's own bone marrow can further augment and accelerate the liver's natural capacity to regenerate itself,' said Günther Fürst, M.D., co-author and professor of radiology.

In the study, researchers compared the results of portal vein embolization (PVE), a technique currently used to help regenerate liver tissue, to a combination of PVE and an injection of bone marrow stem cells into the liver.

PVE blocks blood flow to the diseased portion of the liver and diverts blood to the organ's healthy tissue, promoting liver growth. Bone marrow stem cells extracted from the patient's hip bone and injected into the liver also help the liver regenerate.

The study included 13 patients with large central liver malignancies who were unable to undergo surgery because resection would leave less than 25 percent of their total liver volume.

Six of the patients underwent both PVE and injection of bone marrow stem cells. Seven patients underwent only PVE. Computed tomography (CT) scans were performed before and up to five weeks after PVE to determine the degree of liver growth.

Patients who received the combination of PVE and stem cell injection had double the liver growth rate and gain in liver volume, compared with those who underwent PVE alone. As a result, the patients who received the combined treatment were able to undergo surgery an average of 18 days sooner than patients who received PVE only.

'Our research demonstrates that stem cells are a powerful adjunct to PVE for patients undergoing surgical resection,' said Jan Schulte am Esch, M.D., co-author and surgery staff member. 'Based on our results, we also believe that adult stem cell administration may be a promising therapy for regenerating livers damaged by other chronic and acute diseases.'

The researchers are currently embarking on a randomized controlled trial of the therapy.

Source: Eurekalert
PRI/S

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I am a infectious disease department doctor,have ever treated some patients with primary liver cancer though hepatic artery embolization chemotherapy ,but I don't feel satisfaction at it, I hope I can resolute this problem by stem tranplant technique .since 2005 year,we have carried stem cell tramsplant into execution for 4 cases patients with decompansated cirrhosis ,results were satisfied

Jccy20

Hello,

Do you mind if I contact you directly to inquire about liver hepatitis cancer treatment?

Please can you help me because one of my family member has been diagnosed with advanced liver cancer? Could you please give me your e-mail ID or could anyone there help?

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