New Test May Better Identify Certain Colorectal Cancer Types

by Medindia Content Team on  February 11, 2007 at 3:07 PM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

New Test May Better Identify Certain Colorectal Cancer Types
A new test may more accurately identify colorectal cancer patients with a specific type of gene mutation. These mutations usually indicate that a patient has an inherited form of the disease or may respond to certain cancer drugs differently.

Some people with colorectal cancer have defects in their so-called DNA mismatch repair genes. Researchers test for these mutations by looking for a gene marker called microsatellite instability, which is caused by those gene defects. These mutations indicate that the cancer is likely an inherited condition called Lynch syndrome. It's important to identify patients with Lynch syndrome because they and their family members are at an increased risk of colorectal and other cancers.

Patients with a non-hereditary form of colorectal cancer that shows microsatellite instability tend to have a better prognosis than other cancer patients, but they don't respond to a common cancer drug called 5-fluorouracil.

Rosa M. Xicola, a graduate student at the Germans Trias i Pujol Hospital in Barcelona, and colleagues tested two different methods, a standard method and an experimental method, of identifying patients with microsatellite instability. They found that the experimental method better identified--and more accurately ruled out--patients with defects in DNA mismatch repair genes. Furthermore, their results suggest that an even simpler test could be developed to identify patients with these mutations.

"The improved test could result in more patients being assigned to proper treatment based on their disease profile," the authors conclude.

Source: Bio-Bio Technology
SRI

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Otitis Media Cancer and Homeopathy Colo-rectal cancer - Management Colorectal Cancer Cancer Facts Cancer Colon Polyps Colorectal Cancer Screening Colorectal Cancer Screening with Colonoscopy Colorectal Cancer Screening with Double-Contrast Barium Enema 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive