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Ketoconazole 2% more effective in treating Seborrheic Dermatitis

by Medindia Content Team on  January 28, 2003 at 1:48 PM Drug News   - G J E 4
Ketoconazole 2% more effective in treating Seborrheic Dermatitis
The Department of Dermatopathology in a University Medical Center in Belgium conducted an open randomized study of 330 subjects suffering from severe seborrheic dermatitis or dandruff, to study the effectiveness of Ketoconazole 2% and Zinc pyrithione 1% shampoo. One hundred and seventy one patients were randomized to ketoconazole 2% shampoo and 160 to zinc pyrithione 1% shampoo.
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The researchers found that ketoconazole 2% achieved a significantly better effect with a 73% improvement in the total dandruff severity score compared with 67% for zinc pyrithione 1% at week four. They also found that the recurrence rate of the disease was significantly lower in the group receiving ketoconazole than in the group receiving zinc pyrithione.

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Researchers therefore concluded that Ketoconazole 2% shampoo is significantly better in treating severe dandruff or seborrheic dermatitis of the scalp than is zinc pyrithione 1% shampoo.

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