Reversal of Roles – Humans to Infect Mosquitoes to Mitigate Malaria

by Savitha C Muppala on  December 25, 2006 at 3:24 PM Research News
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Reversal of Roles – Humans to Infect Mosquitoes to Mitigate Malaria
A novel strategy to combat malaria is abuzz, and the main action plan of this strategy will use humans to infect mosquitoes.

The researchers from the National Institutes of Health have come out with a vaccine that when tested on mice, instigated them to produce antibodies against the parasite, Plasmodium falciparum which causes malaria. The antibodies created in the body of the mice, gain access into the mosquito's body, through the bite. The antibodies then attack the parasite in the mosquito's gut.

According to the researchers, the parasites are destroyed even before they could reach the salivary glands of the mosquitoes. Therefore the parasite is not transmitted through bites.

Dr. Owen M. Rennert of the NIH's National Institute of Child Health & Human Development said, "This is a very reasonable approach. I think it has a shot at being an answer." The mouse vaccine was developed using the conjugate technology, which connects molecules so that they are identified by the immune system.



Source: Medindia
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