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Human Uterine Transplant In Near Future

by Gayatri on  November 10, 2006 at 11:30 AM Organ Donation News   - G J E 4
Human Uterine Transplant In Near Future
U.S. doctors have been permitted to perform womb transplantation on human patients. This follows the first successful transplant on a non-human primate, a rhesus monkey, last month by a team of researchers from New York and Pittsburgh.
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The review board at New York Downtown Hospital has given permission to Dr Giuseppe Del Priore to carryout transplant on people. He even has potential donors lined up, reveals New Scientist magazine.

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Women undergoing the transplant would be given the healthy womb from a person who died. The uterus would be connected to the recipient's blood supply and immunosuppressant drugs would be given to avoid graft rejection. Once the recipient has had one or two kids successfully, the womb would be removed and she would be taken off the powerful immunosuppressants.

Dr Del Priore, an assistant professor of gynaecologic oncology, has performed a transplant in a rhesus monkey along with colleagues at Pittsburgh University. The womb was observed for 20 hours. It had a healthy blood supply and the animal's immune system had accepted the organ under the action of the immunosuppressant drugs.

In spite of critics doubting the technique and wanting more research to be done before performing on humans, Professor Giuseppe Del Priore, of Downtown Hospital, insisted it is now technically possible. 'If a person walked in tomorrow and requested a uterine transplant I am cautiously optimistic we could be successful,' he told New Scientist magazine, published today.

'While the monkey transplant is successful, I plan to ensure the transplanted uterus is able to function properly by following a pregnancy in a rhesus monkey to term, even though this further test is not strictly necessary to prove the safety of the technique in humans,' said Prof Del Priore.

Richard Smith, a gynaecologist at London's Hammersmith Hospital, claimed in September that he would carry out a uterine transplant in 2 years time.

Mats Brannstrom of Gothenburg University, Sweden, who has been working on uterine transplants for six years, says, 'We have to do a lot more animal studies before we go on to humans.' In 2002, his team performed the world's only uterine transplant that that was followed by successful pregnancy in mice.

Womb transplantation was carried out unsuccessfully in 2000 in Saudi Arabia. The uterus had to be removed due to the development of a blood clot in one of the connecting blood vessels.

IVF combined with surrogacy is the only method available at present for a woman without a functioning womb.

Source: Medindia
GYT
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The World's First Live Birth after a Uterine Allo-transplatation in the Sheep‏ Go to YouTube Play video PRESS RELEASE Edwin Ramirez, MD, is a world renowned pioneer of Uterine Transplant Research with a special interest in fertility preservation and minimally invasive surgery. He is also a second generation Obstetrician and Gynecologist who has pioneered a new breakthrough procedure which in the future will aid patients with Reproductive problems. After 11 years of research, Dr. Ramirez's surgical team have demonstrated that a pregnancy can be carried for the first time in history in a transplanted uterus under the influence of immunosuppressive therapy in the sheep model. His groundbreaking news has been published in the Journal of Minimally Invasive Gynecology which is an international journal with a reputation of accepting "cutting-edge medicine" from the brightest minds in gynecologic surgery. Dr. Ramirez has been invited as a guest speaker to several national and international meetings to share his and his fathers theory to the medical community. The concept of uterine transplantation has been reserved as a central intervention for patients who were either born without a uterus [Rokitansky sydrome] or had their uterus removed at an early reproductive age. Adoption and surrogacy has been provided as another alternate to help these individuals experience motherhood however these services may not be suitable for a given population due to cultural/religious beliefs or demographic location. The Ramirez project initially started as a family project and now expanding as a multi-center study where they soon hope to demonstrate that a uterine transplant can successfully be performed in the non-human primate. Involved in this project is his father Dr. Hugo Ramirez (Pioneer), sister Dr. Doris Ramirez Nessetti, bother-in-law Dr. Matthew Nessetti and Dr. Masood Khatamee. The American Congress of Obstetricians and Gynecologists has invited Dr. Ramirez to present his work at the 59th Annual Clinical Meeting in Washington, DC. Currently, Dr. Edwin Ramirez is practicing as an obstetrician and gynecologist in Oxnard, California. Edwin Ramirez, MD Rassetti Gynecology Oxnard, California 93030 Work (805) 278-0190Fax (805) 278-6291 Cell 432-5671095 email: edramirezmd@aol.com
www.uterinetransplant.com Tuesday, April 26, 2011
I was 22 when I had my hysterectomy due to severe endo and pcos. I never had the opportunity to have children and that is my only dream is to have that motherhood feeling to feel what my husband and I made inside me and to see the little baby grow up this is something that I have tore myself up over everyday since the surgery three years ago. Please I beg you if there is any hope for me to be apart of the study and any hope that I could bear children please help me. This would be the greatest gift I could ever hope for. I would then feel like it wasn't stolen from me. My email is jessicadkhalaf@yahoo.com please consider I don't care if everything is experimental I will do just about anything to help myself and many other women like me.
Jessicadkhalaf Friday, January 21, 2011
i would really appreciate being picked for this treatment as after having 3 kids 2 miscarriages and a hysterectomy by 27 i am desperate for more children to the point i would try anything.
chazaw Tuesday, July 20, 2010
I would also like to be a candidate for this procedure. I am a healthy 22 year old woman, who had to have a hysterectomy when I was twenty. My husband and I would love to have children.
FMAR13 Tuesday, June 8, 2010
I would love to have a uterus Transplant.I had a miscarriage at 2 months, and due to the doctor's negligence had a partial hysterectomy. So I will never carry a child. I would do anything to get that opportunity. It would be great if I could sign up for a transplant and would consider it as a gift of the Lord.
lostbabe5 Friday, May 21, 2010
I had my uterus removed at the age of 31, when I lost my 2 month pregnant baby. I was diagnosed with fibroid and had a hysterectomy.I would gladly sign up to be a candidate for this.
Racheal1978 Sunday, March 14, 2010
I had radical hysterctomy at 26 and I am now 39. I would love to be a candidate for this procedure. I also had my ovaries removed and would love to have transplant as well.
Please advise.

kt

kt_inyahti Friday, March 5, 2010
i would love to be a volunteer for uterine transplant, i had to have a hysterectomy at age 26 due to a high rish pregnancy, i'm now 30 and had almost given up on the thought of having a child until i read this article on uterine transplant...all i can say is this would be such a dream come true for so many women, no matter what i would have to go through, to have one child at the end would make it all worth it.
guest Monday, December 7, 2009
I would more than gladly volunteer for the procedure. I am a healthy 33 year old. I will marry the man of my dreams on Dec 15, 2009 and would give anything to be able to have a baby. It would be a miracle and hope for so many couples. I have faith that it will happen.
zuzuspetals Monday, November 23, 2009
I'd give anything to have this! Like many before have said I was born without a uterus but other than that I'm young and healthy! Surrogacy at this point is my only hope...but this isn't ideal and I'd love to carry my own baby.
Kat89 Thursday, October 22, 2009

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