Effect of drug on Renal Cancer

by Medindia Content Team on  August 16, 2002 at 5:45 PM General Health News
RSS Email Print This Page Comment
Effect of drug on Renal Cancer
According to the researchers of University of Houston, a new study shows thalidomide at higher doses in kidney cancer patients is associated with manageable side effects. The study also shows long-term use may lead to neuropathy.They examined the effects of escalating thalidomide doses in kidney cancer patients. Patients received oral thalidomide starting at 200 mg per day. Researchers increased the dose by 110-200 mg per day until a target dose of 1,300 mg per day was reached.
Advertisement

The most common, but reversible, side effects were constipation, drowsiness and fatigue. Peripheral neuropathy, a neurological disorder, was seen after prolonged therapy. As a result, doses were reduced. The study also shows survival was longer in patients with higher hemoglobin levels but shorter in patients with multiple organ involvement and previous treatments.

Advertisement
Renal cancer is an incurable disease that responds sickly to systemic treatment. Thalidomide is one of several drugs that inhibit angiogenesis, the development of new blood vessels. Researchers say angiogenesis inhibition may be therapeutic for patients with kidney cancer. Researchers are hereby hoping that by blocking the development of new blood vessels, in order to cut off the tumor's supply of oxygen and nutrients, and therefore stop its prolonged growth and spread to other parts of the body.

Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Drug Toxicity Cancer and Homeopathy Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Signature Drug Toxicity Cancer Facts Cancer Renal Cell Carcinoma Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant 
Advertisement

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive