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Improving Treatment Options for Multiple Sclerosis

by Medindia Content Team on  August 8, 2006 at 2:04 PM Mental Health News   - G J E 4
Improving Treatment Options for Multiple Sclerosis
A cellular signal is thought to worsen the symptoms of MS, say researchers, who have zeroed in on a genetic approach that holds promise in the development of novel strategies to treat this severe neurological disease, for which a concrete cure is not yet in place.
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The study has indicted that an exercise to effectively impede the protein that is in charge of managing the signal, might be the key to unlock a new strategy to treat Multiple Sclerosis. Italian and German scientists worked on one important molecule, behind MS, which is called NF-kB. They investigated the effects of blocking this molecule in mice that portrayed MS like symptoms.

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Pasparakis, a former Group Leader at EMBL's Mouse Biology Unit said, " We have known for a long time that NF-kB is crucially involved in MS, but until now it was not clear if it was friend or foe."

The findings revealed that there was a certain reduction in MS symptoms, which is thought to relate to a reduced amount of inflammatory messengers emanating in the brain.

In the words of Pasparakis, "This was quite a challenge because NF-kB is involved in many crucial processes throughout the entire body, and shutting down its activation in all cells kills the mouse before it is born. To observe the effect of NF-kB in MS, we used sophisticated genetic techniques to generate mice that do not express IKK2 and NEMO in brain cells only."

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What is the exercise and is it applicable with any case studies?
guest Saturday, August 12, 2006

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