Muscular Dystrophy Reversed In Lab Mice

by Medindia Content Team on  July 31, 2006 at 10:42 AM Research News
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Muscular Dystrophy Reversed In Lab Mice
A new study appearing in Nature Genetics says that researchers have found a way to reverse muscular dystrophy (MD) in laboratory mice. This discovery kindles hope that a cure for the human form of the disease may be found.

The University of Virginia researchers said that the therapy used by them could fully restore heart and skeletal muscle function. "The results represent the first in vivo proof of principle for a therapeutic strategy for treatment of myotonic dystrophy by ablating or silencing expression of the toxic RNA molecules,' the authors said.

In MD there is a faulty DNA, which is responsible for almost all of the abnormalities. This therapy targeted a specific molecule and silenced it during the course of the disease.

Lead researcher Dr Mani Mahadevan and his team found that toxic mRNA causes the disease and they also found a way to turn it off in mice. "The fact that the course of the disease can be reversed both overtly and at the molecular level suggests that the toxic RNA functions as a reversible metabolic toxin," the researchers said.

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Hi,My name is M.Ehsan and i live in Pakistan.my younger brother (17 years) had been prescribed BECKER MUSCULAR DYSTROPHY.We were told that there is no treatment for this disease all over the world.His case history is as under - No Family History(No one in family had MD before ) - Diagnosed 3 years before. - Age 17 years - He can walk, but feel difficulty in walking and climbing stairs. - Sometime fell on ground while walking and then put both his hands on his knees and then gets up with difficulty. - His blood C.P.K is 4000.(checked two months ago Now i read about your research in MD so i find a hope and tried to contact you.Can you help us in this regard? Somehow if we can cure this disease, OR reduce his rate of weakness and muscle destruction. OR anything that can help to make his life Normal. We can come to you Hospital/Clinic, if you think it can help in treatment. Kindly help us in this regard, we would be very thankful to you for this kind response and help. Anxiously waiting for your reply. Thanks M.Ehsan

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Muscular Dystrophy Genetic Testing of Diseases Dysarthria 

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