A New Anti-Cancer Drug Keeps Resistance Out

by Medindia Content Team on  June 15, 2006 at 2:26 PM Cancer News
RSS Email Print This Page Comment
A New Anti-Cancer Drug Keeps Resistance Out
An experimental drug named Dasatinib, developed by Bristol-Myers Squibb company offers a valuable treatment against the signs and symptoms of chronic myeloid leukemia patients than the usual drug named Gleevec.
Advertisement

Patients, who are resistant to Gleevec drug can now be treated with dasatinib, which seems to regulate intolerance and complications of chronic myeloid leukemic patients - studies published in NEJM finds.

Advertisement
In the phase I clinical trials dasatinib overcome Gleevec resistance in about 68 of 84 patients studied - study leader, HHMI investigator Charles L. Sawyers, and colleagues at UCLA's Jonsson Comprehensive Cancer Center, reported.

People in all 3 stages of the disease such as chronic phase, the accelerated phase, and blast crisis respond to the new drug quite possibly, Sawyers says.

Sawyers said, 'Drug-related mutations are better understood by the application of experimental drug, dasatinib to subjects and even individual patient's mutation type were easily studied by scientists at Bristol-Myers Squibb'.

'How drug target mutation take place and whether molecular explanation of drugs has any role to play in it' all studied by the scientists, showing improvements in structural biology studies.

Due to being as a 'sloppier inhibitor' meaning - does not hold its target to such tight structural constraints, dasatinib differs from the drug Gleevec.

Sawyers added dasatinib proves its value to overcome kinase resistance in managing cancer patients and also keep rooting in other fields of medicine like molecular oncology and structural biology.

Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Drug Toxicity Signature Drug Toxicity Top 10 Health Benefits of Cloves 
Advertisement

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive