Australian researchers found that anti-cancer effects of exercise results from an increase in a protein called insulin-like binding protein-3 (IGFBP-3) that blocks cell growth and cause cell death.
A study reports 'Insulin-like binding protein-3 (IGFBP-3), which is a protein that inhibits the action of another protein called insulin-like growth factor-1 (IGF-1), blocks IGF-1's proliferative effect on cell growth, due to which the result appears.
In the Melbourne Collaborative Cohort Study, Dr. Andrew M. M. Haydon and colleagues at Manash Medical School in Melbourne found out new cases of colorectal cancer in studying 41,528 adults during the year 1990-1994.
Analysis of 443 colon cancer patients for a period of more than 5 years were carried out for the comparison of baseline levels of IGF-1or IGFBP-3 with baseline body mass index and level of physical activity. Physically active subjects showed an increase in IGFBP-3 with a 48 percent reduction in colon cancer-specific deaths. No association was apparent for IGF-1.Physically inactive subjects showed no correlation and positive results.
Physical activity increases IGFBP-3 levels. IGFBP-3 reduces the amount of free IGF-1, which, in turn, has been shown to stimulate cell growth, inhibit cell death, and promote angio genesis (formation of new blood vessels). And this study looked dose-effect and effect of physical effect - Haydon elaborates.