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Herceptin + Hormonal Therapy Pack Reduces Breast Cancer Progression

by Medindia Content Team on  May 30, 2006 at 11:59 AM Cancer News   - G J E 4
Herceptin + Hormonal Therapy Pack Reduces Breast Cancer Progression
In a new study, Roche Holding AG (RHHBY), a Swiss pharmaceutical company says, breast cancer progression decreases when Herceptin was added to hormonal therapy. When the patient condition is hormone receptor-positive, as well as HER2-positive, this combined therapy proves to be progression-free. Hormone receptor-positive breast cancer results lower risk rate whereas HER2-positive breast cancer aggressive form of the disease that requires special and immediate attention due to fast- developing tumour.
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Eduard Holdener, Global Head of Roche Pharma Development reported that a combination therapy proved a new better treatment for breast cancer patients, who suffer from an extremely aggressive form of the disease. AII over the world nearly above 230,000 patients with HER2-positive breast cancer are trailed for treatment with Herceptin. And whether used alone or with other combination of therapies Herceptin consistently benefits patients.

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Across the world, in 25 countries about 208 HER2 and hormone receptor co-positive patients were enrolled at 134 sites.The randomised, Phase III trial, conducted by Roche started in 2001 which evaluated Herceptin plus Arimidex versus Armidex alone as first-line therapy -or second line hormonal therapy- in postmenopausal women with advanced, HER2-positive and hormone receptor-positive breast cancer -TAnDEM study reports.

Arimidex - a dose of 1 mg daily and Herceptin a dose of 2 mg/kg weekly were given after an initial loading dose of 4 mg/kg, until disease progression. At the end, patients who received Herceptin had a statistically significant improvement in progression-free survival.

Overall safety data and side-effects were continued to be followed.

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