Medindia

X

Foremost gene therapy for chest pain

by Medindia Content Team on  March 4, 2002 at 2:28 PM General Health News   - G J E 4
Foremost gene therapy for chest pain
Based on a study on angina patients, it was found that transferring growth factor genes into the heart is safe and improves exercise tolerance. In angina, the blood supply to the heart is limited, leading to pain on exertion. Initially the body tries to compensate by growing new blood vessels to bypass the restricted area. But, for some unknown reason, this process, known as angiogenesis, soon switches off again.
Advertisement

Researchers at the Hopkins University, have been developing a form of gene therapy to try to restart angiogenesis. They injected a gene for a growth factor that stimulates blood vessel generation into 70 men and women with angina. A further 20 people acted as controls.

Advertisement
The gene therapy proved safe - the gene itself, introduced via a virus 'carrier', stayed in heart tissue. What's more, there were small but significant increases in exercise tolerance - as measured by a treadmill test - in those receiving the gene therapy. This was just a small study which needs to be repeated in a larger group, but the results look highly encouraging.

Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All