Abnormal low-density lipoprotein(LPD), lipid composition and anti-oxidant content are associated with an increased liability to oxidation of LDL derived from diabetic patients.Researchers designed a study to compare the oxidation of LDL drawn from patients with diabetes mellitus to normoglycemic controls. They also sought to follow-up the effects of dietary beta-carotene supplementation on LDL oxidation. Researchers say that natural Beta-carotene supplementation may delay atherosclerosis In Diabetics.
Participants included 20 patients who were non-insulin-dependant diabetics and age-sex-matched control subjects. For three weeks patients received a supplement of dunaliella bardawil-derived beta-carotene 60 mg once daily.
The oxidation of low-density lipoprotein was analysed. Researchers also measured LDL lipid composition and the low-density lipoprotein associated vitamins A, E and carotenoids. Beta-carotene supplementation produced significant elevation in plasma and in LDL all-trans beta-carotene, paralleled by a significant reduction in LDL susceptibility.
Researchers concluded that natural beta-carotene dietary supplementation normalises the enhanced low-density lipoprotein and may be important in delaying accelerated development of atherosclerosis in patients with diabetes mellitus.