Use of Antioxidants to Stabilize Fanconi Anemia

by Sheela Philomena on  May 16, 2012 at 10:01 AM Research News   - G J E 4
Combination of lipoic acid and N-acetylcysteine can stabilize the DNA of blood cells from Fanconi anemia (FA) patients, says study published in Rare Diseases.
 Use of Antioxidants to Stabilize Fanconi Anemia
Use of Antioxidants to Stabilize Fanconi Anemia

15 genes are known to be involved in FA. These genes are responsible for repairing DNA and because FA patients do not repair DNA efficiently they are more susceptible to diseases caused by DNA mutation, including cancer, especially leukemia. Mitochondria, the 'power houses' of the cell, are also affected by FA and consequently patients have an impaired ability to detoxify mutagenic chemicals before they can damage DNA.

Researchers from The University of Porto worked with local hospitals to obtain white blood cells from FA patients. Filipa Ponte, who performed the research, in association with Beatriz Porto and Félix Carvalho, explained, "Pre-treating cells with the antioxidants α-LA and NAC (or to a lesser extent α-LA or NAC individually) significantly reduced the number of spontaneous DNA breaks in blood cells taken from patients with FA and from normal controls. α-LA is essential for metabolism and NAC breaks disulfide bonds and consequently is used in treating paracetamol overdose to prevent liver damage. In fact, a cocktail of α-LA and NAC was able to reduce chromosome instability by at least 60%."

She continued, "These results show that α-LA plus NAC cocktail may be useful to keep chromosome stability in FA patients, which could help block or delay the progression of the disease. This cocktail may be even more effective when applied to FA mosaics and FA chimeras, after bone marrow transplant, as we observed in vitro."

Source: Eurekalert

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like