Unusual Mutation Linked to Liver Cancer in Adolescents Discovered

by Kathy Jones on  February 28, 2014 at 9:07 PM Genetics & Stem Cells News
RSS Email Print This Page Comment bookmark
Font : A-A+

A joint study conducted by researchers at The Rockefeller University, Memorial Sloan Kettering Cancer Center and the New York Genome Center (NYGC) has has led to the discovery of an unusual mutation that can be linked to a rare liver cancer which affects teens and young adults.
 Unusual Mutation Linked to Liver Cancer in Adolescents Discovered
Unusual Mutation Linked to Liver Cancer in Adolescents Discovered

Fibrolamellar is a rare liver cancer that affects just 200 people every year and there are no known causes and it very difficult to detect or treat. The researchers recruited around 15 people diagnosed with the disease and sequenced their RNA and DNA. They discovered that a portion of the DNA had been broken and rejoined, creating a mutated gene that was present in all the 15 patients and had the potential to wreak havoc in the bodies of individuals with the gene.

Elana Simon, who was part of the Rockefeller team and had been diagnosed with the disease six years ago, said that the mutated gene was linked with a kinase, an enzyme that modifies other proteins and overproduction of this kinase may lead to uncontrolled growth of the tumor.

"Because of the deletion and then rejoining of the DNA, a new gene that was a mixture of two previous genes was created, called a chimera. A number of other types of tumors have been shown to be driven by chimeras, but this one is unique — it codes for a kinase, an enzyme that modifies other proteins, that has not been identified in cancers", Elana said.


Source: Medindia

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Alcoholic Liver Disease Hepatitis A Hepatitis B Liver Cancer Cancer and Homeopathy Neonatal Jaundice Bubbles and Brews - Alcohol Facts Cancer Facts Cancer Tattoos A Body Art 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive