Treating brain cancers and many
other difficult-to-treat infectious diseases is now possible, say scientists. A
new method has been discovered in using drugs to attack a protein in cancer
cells, bacteria and virus.
It is possible to target the
Protein called GRP78 and related proteins using drug combinations of Viagra,
Cialis and OSU-03012 (AR-12) (clinically tested) in treating deadly diseases
like Ebola infection, brain cancer, influenza, hepatitis and infections caused
by the superbug bacteria - evidenced from study conducted by Virginia
Commonwealth University and published in the Journal of Cellular Physiology
Researches have found that in mice,
the said drug combination kills tumour cells without affecting the normal
tissues. They are likely to find more from the findings.
Study Investigators and Data
"Basically, we've got a concept
that by attacking GRP78 and related proteins: (a) we hurt cancer cells; (b) we
inhibit the ability of viruses to infect and to reproduce; and (c) we are able
to kill superbug antibiotic-resistant bacteria," said the study's lead
investigator, Paul Dent, professor in the department of biochemistry and
molecular biology at VCU School of Medicine, and Universal Chair for Signal
Data was obtained in: Ebola,
influenza, multiple brain cancer stem cell types, measles, mumps, respiratory
syncytial virus (RSV), rubella, cytomegalovirus (CMV), adenovirus, coxsakie
virus, hepatitis, chikungunya, E. coli, MRSE and N. gonorrhoeae, MRSA and
When trying the OSU/viagra drug
combination with viral disease, it reduced infectivity by averting virus
replication and reduced expression of viral receptors for hepatitis A, B and C,
Ebola, Marburg and viruses of Lassa fever.
"The findings open an avenue of
being able to treat viral infections, infections that certainly most people
would say we'll never be able to treat; they prove that GRP78 is a "drugable"
target to stop viruses from reproducing and spreading," Dent explained.
"In the case of bacteria, we have a new antibiotic
target, Dna K, that if we're careful and only use the OSU drug in hospitals,
we've got something that can help to treat the superbugs," he added.