Understanding the Mechanisms of Alzheimer's Disease

by Bidita Debnath on  June 12, 2013 at 7:40 PM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

In the brains of Alzheimer's disease (AD) patients the accumulation of amyloid-β (Aβ) is known to be associated with memory loss and neuronal degeneration, but the mechanism of Aβ pathogenesis is not fully understood.
 Understanding the Mechanisms of Alzheimer's Disease
Understanding the Mechanisms of Alzheimer's Disease

In this issue of the Journal of Clinical Investigation, researchers led by Yong-Keun Jung at Seoul National University demonstrate that Aβ binds to a cellular protein known as FCγRIIb. Greater levels of FCγRIIb were detected in the brains of AD patients.

Binding of Aβ to FCγRIIb activated cell stress and death pathways. In a mouse model of AD, depletion of FCγRIIb ameliorated memory impairment. This study demonstrates that FCγRIIb plays a critical role in AD pathogenesis.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Alzheimers Disease Diet and Alzheimer´s Disease Genetics of Alzheimer´s disease 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive

Loading...