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Understanding the Mechanisms of Alzheimer's Disease

by Bidita Debnath on  June 12, 2013 at 7:40 PM Research News   - G J E 4
In the brains of Alzheimer's disease (AD) patients the accumulation of amyloid-β (Aβ) is known to be associated with memory loss and neuronal degeneration, but the mechanism of Aβ pathogenesis is not fully understood.
 Understanding the Mechanisms of Alzheimer's Disease
Understanding the Mechanisms of Alzheimer's Disease
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In this issue of the Journal of Clinical Investigation, researchers led by Yong-Keun Jung at Seoul National University demonstrate that Aβ binds to a cellular protein known as FCγRIIb. Greater levels of FCγRIIb were detected in the brains of AD patients.

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Binding of Aβ to FCγRIIb activated cell stress and death pathways. In a mouse model of AD, depletion of FCγRIIb ameliorated memory impairment. This study demonstrates that FCγRIIb plays a critical role in AD pathogenesis.

Source: Eurekalert
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