Scientists at UCLA have developed a new technique for creating
patient specific combination drug regimens that, at least in laboratory tests,
have shown more effective than existing techniques.
Moreover, to make the drug therapy even more powerful, the research
team used nanodiamonds in helping to deliver drugs to neoplastic cells.
The so-called Feedback System Control.II uses phenotypic
information in evaluating the effectiveness of a particular drug combination.
Once the optimal combo therapy has been identified, the drugs are assembled
along with nanodiamonds attached to their surface.
The compounds were introduced to cancer cell lines and the
nanodiamonds acted as anchors that prevented the drugs from being excreted by
the cancer cells. This allowed the drug therapy to act for longer periods of
time, getting the most out of each drug payload without harming as many healthy
Combination therapy, particularly in cancer treatment, is a common
way of attacking aggressive diseases, but they often miss their targets.
"This optimized nanodrug combination approach can be used for
virtually every type of disease model and is certainly not limited to cancer.
Additionally, this study shows that we can design optimized combinations for
virtually every type of drug and any type of nanotherapy," said Dr. Chih-Ming
Ho, a professor of mechanical engineering at UCLA.