Drug Improves Survival Rates In Heart Failure Patients

Aliskiren, the drug that inhibits the enzyme that regulates blood pressure, delays the progression of congestive heart failure and improve survival rates, according to preclinical studies conducted by the team of researchers at the University of Arizona College of Medicine - Phoenix.//

More than 5 million Americans live with congestive heart failure, a chronic progressive condition that occurs when the heart muscle doesn’t pump blood as well as it should.

‘Muscle wasting and fluid retention in heart failure patients could be addressed by the new drug Alsikerin. This FDA-approved drug has the potential to improve the quality and extend the life of these patients.’
Read More..

Tweet it Now

"This FDA-approved drug has the potential to improve the quality and extend the life in properly identified heart failure patients," said Ryan Sullivan, DVM, assistant professor in the college’s Department of Internal Medicine and lead author of the study, "Normalizing Plasma Renin Activity in Experimental Dilated Cardiomyopathy: Effects on Edema, Cachexia, and Survival," published in the International Journal of Molecular Sciences, as part of a Special Issue Heart Failure: From Molecular Basis to Therapy.

"That’s an extra 5.6 years with loved ones that otherwise would not be possible. Obviously, further studies are needed, along with human clinical trials, but we are excited about our research direction and what those outcomes could mean for the college and the people of Arizona and beyond."

The Cardiovascular Disease Research group from the UA College of Medicine - Phoenix Department of Internal Medicine used a new technology to evaluate changes in muscle mass and fluid retention over time in heart failure. Using this noninvasive technology, they showed that Aliskiren blocked muscle loss, prevented fluid retention and saved lives.

"Heart failure is a rapidly increasing cause of disability and death," Dr. Sullivan said. "Patients suffer from progressive muscle wasting and fluid retention, which leads to discomfort, shortness of breath and fatigue. There is a need to better measure muscle wasting and fluid retention to identify effective methods for treatment and prevention. These exciting findings demonstrate new approaches that may guide future care for heart failure patients."

Edema and muscle wasting occur during the progression of heart failure and neither is always clinically evident.

Congestive Heart Failure (Congestive Cardiac Failure) Current Management
Congestive heart failure (CHF) is a condition in which the heart fails to work adequately as a pump that can deliver oxygen rich blood to the body.

One of the major challenges in heart failure management is detecting and reproducibly quantifying edema and muscle mass over time in response to interventions that treat breathlessness, clinical symptoms of heart failure and cardiac cachexia, which is unintentional severe weight loss associated with heart failure.

The team identified and implemented the technology known as QMR (quantitative magnetic resonance) as a method to objectively measure edema development longitudinally throughout the disease progression. In addition, the device captures changes in body fat and lean muscle mass, which are associated with poor prognosis in heart failure patients.

This technology has potential applications in monitoring and adjusting individual treatment protocols by using a precision medicine approach for clinical heart failure patients.

Source-Eurekalert