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Toll-like Receptor 4 Plays Vital Role in Neuroinflammation

by Bidita Debnath on  July 16, 2013 at 6:37 PM Research News   - G J E 4
New study suggests that Toll-like receptor 4 expressed in the central nervous system, especially in glial cells, plays a vital role in neuroinflammation and neurodegenerative conditions.
 Toll-like Receptor 4 Plays Vital Role in Neuroinflammation
Toll-like Receptor 4 Plays Vital Role in Neuroinflammation
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Traditional theory suggests that neurons are injured by inflammatory factors released from glial cells and that neurons are the victims of neuroinflammation. However, it has recently been suggested that Toll-like receptor 4 is expressed by cerebral cortical neurons. Yae Hu and team from Medical School of Nantong University found that lipopolysaccharide participates in neuroinflammation by stimulating Toll-like receptor 4/nuclear factor-κB pathway in hippocampal neurons.

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Researchers believe that neurons may be both "passive victims" and "activators" of neuroinflammation. These findings were published in the Neural Regeneration Research (Vol. 8, No. 16, 2013).

Source: Eurekalert
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