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Through MicroRNA Modulation Promotes Oncogenesis In Hepatitis B Virus

by Rukmani Krishna on  January 18, 2013 at 11:57 PM Genetics & Stem Cells News   - G J E 4
By genetically altering infected cells viruses prompt oncogenic transformation. Viruses alter the expression of microRNAs, non-coding RNA molecules that can block the expression of target genes finds several studies.
 Through MicroRNA Modulation Promotes Oncogenesis In Hepatitis B Virus
Through MicroRNA Modulation Promotes Oncogenesis In Hepatitis B Virus
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In this issue of the Journal of Clinical Investigation, Xiaoje Xu and colleagues at the Beijing Institute of Biotechnology report that miR-148a is repressed by hepatitis B virus (HBV) X protein (HBx) to promote growth and metastasis of liver cancer. In normal liver cells, miR-148a represses the expression of the oncogenic protein HPIP, but the hepatitis B virus prevents expression of miR-148a, leading to increased levels of HPIP and subsequent oncogenic transformation. This study demonstrates that a cancer-associated virus promotes carcinogenesis through direct manipulation of a microRNA.

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Source: Eurekalert
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