Therapeutic Changes in Glioma Mice After Transplantation of Neural Stem Cells: Researchers

by Rukmani Krishna on  August 14, 2013 at 11:59 PM Cancer News
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Tumor cell growth and prolife-ration can be hindered by neural stem cells transplanted into tumor-bearing rats; however, the mechanism remains unclear. Abnormal activation of the Ras/Raf/Mek/Erk signaling cascade plays an important role in glioma.
 Therapeutic Changes in Glioma Mice After Transplantation of Neural Stem Cells: Researchers
Therapeutic Changes in Glioma Mice After Transplantation of Neural Stem Cells: Researchers
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Inhibition of this aberrant activity could effectively hinder glioma cell proliferation and promote cell apoptosis. To investigate the mechanism of glioblastoma treatment by neural stem cell trans-plantation with respect to the Ras/Raf/Mek/Erk pathway, Hua Li and team from the 476 Hospital of Chinese PLA observed Raf-1, Erk and Bcl-2 protein expression as well as Caspase-3 protein expression. The researchers found that transplantation of neural stem cells could inhibit the abnormal activation of Ras/Raf/Mek/Erk signaling, thus promoting apoptosis and potentially treating glioma. These findings are published in the Neural Regeneration Research (Vol. 8, No. 19, 2013).

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Source: Eurekalert
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