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The Saga of Adenoid Cystic Carcinoma

by Bidita Debnath on  June 19, 2013 at 4:35 PM Research News   - G J E 4
Adenoid cystic carcinoma (ACC) is a slow-growing and often fatal malignancy. It is most frequently found in the salivary glands and can occur at multiple organ site.
 The Saga of Adenoid Cystic Carcinoma
The Saga of Adenoid Cystic Carcinoma
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The primary treatment is surgical removal; however, the majority of patients develop metastatic disease. In this issue of the Journal of Clinical Investigation, researchers led by Andrew Futreal at the Wellcome Trust Sanger Institute in Cambridge, MA, performed a type of genetic sequencing known as whole exome sequencing of 24 ACC cases.

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They identified a genetic translocation that can precipitate disease and determined that a large number of disease-associated mutations occurred in genes that modify DNA. In the accompanying commentary, Henry Frierson, Jr. of the University of Virginia emphasizes that identifying individual mutations will aid the development of personalized therapy.

Source: Eurekalert
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