The Chemical Behind Cancer Resistance in Naked Mole Rats Identified By Scientists

by Rukmani Krishna on  June 23, 2013 at 10:40 PM Cancer News
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The chemical behind cancer resistance was identified by Gorbunova and Seluanov as HMW-HA, which caused them to test its possible role in naked mole rat's cancer resistance.
 The Chemical Behind Cancer Resistance in Naked Mole Rats Identified By Scientists
The Chemical Behind Cancer Resistance in Naked Mole Rats Identified By Scientists
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Seluanov and Gorbunova then showed that when HMW-HA was removed, the cells became susceptible to tumors, confirming that the chemical did play a role in making naked mole rats cancer-proof. The Rochester team also identified the gene, named HAS2, responsible for making HMW-HA in the naked mole rat. Surprisingly, the naked mole rat gene was different from HAS2 in all other animals. In addition the naked mole rats were very slow at recycling HMW-HA, which contributed to the accumulation of the chemical in the animals' tissues.

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The next step will be to test the effectiveness of HMW-HA in mice. If that test goes well, Seluanov and Gorbunova hope to try the chemical on human cells. "There's indirect evidence that HMW-HA would work in people," said Seluanov. "It's used in anti-wrinkle injections and to relieve pain from arthritis in knee joints, without any adverse effects. Our hope is that it can also induce an anti-cancer response."

Source: Eurekalert
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