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The Benefits of Vitamin D in Reducing Inflammation

by Savitha C Muppala on  February 28, 2012 at 9:59 AM Research News   - G J E 4
Scientists have found the beneficial effects of Vitamin D in reducing inflammation.

Scientists showed in their experiments that low levels of Vitamin D failed to inhibit the inflammatory cascade, while levels considered adequate did inhibit inflammatory signaling.
 The Benefits of Vitamin D in Reducing Inflammation
The Benefits of Vitamin D in Reducing Inflammation
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"This study goes beyond previous associations of vitamin D with various health outcomes. It outlines a clear chain of cellular events, from the binding of DNA, through a specific signaling pathway, to the reduction of proteins known to trigger inflammation," said study lead author Elena Goleva, assistant professor of pediatrics at National Jewish Health.

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"Patients with chronic inflammatory diseases, such as asthma, arthritis and prostate cancer, who are vitamin D deficient, may benefit from vitamin D supplementation to get their serum vitamin D levels above 30 nanograms/millilitre," she said.

Researchers examined the specific mechanisms by which vitamin D might act on immune and inflammatory pathways. They incubated human white blood cells with varying levels of vitamin D, then exposed them to lipopolysaccharide (LPS), a molecule associated with bacterial cell walls that is known to promote intense inflammatory responses.

Cells incubated with no vitamin D and in solution containing 15 ng/ml of vitamin D produced high levels of cytokines IL-6 and TNF-alpha, major actors in the inflammatory response. Cells incubated in 30 ng/ml vitamin D and above showed significantly reduced response to the LPS. The highest levels of inflammatory inhibition occurred at 50 ng/ml.

Through a complex series of experiments, the researchers identified a new location where the vitamin-D receptor appears to bind directly to DNA and activate a gene known as MKP-1. MKP-1 interferes with the inflammatory cascade triggered by LPS, which includes a molecule known as p38, and results in higher levels of IL-6 and TNF-alpha.

The results of the study were reported in the March 1, 2011, issue of The Journal of Immunology.

Source: ANI
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